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Journal of Virology, September 2008, p. 9293-9298, Vol. 82, No. 18
0022-538X/08/$08.00+0     doi:10.1128/JVI.00749-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Differential Antigen Presentation Kinetics of CD8+ T-Cell Epitopes Derived from the Same Viral Protein{triangledown}

Jonah B. Sacha,1 Matthew R. Reynolds,1 Matthew B. Buechler,1 Chungwon Chung,1 Anna K. Jonas,1 Lyle T. Wallace,1 Andrea M. Weiler,1 Wonhee Lee,1 Shari M. Piaskowski,1 Taeko Soma,1 Thomas C. Friedrich,1 Nancy A. Wilson,1 and David I. Watkins1,2*

Wisconsin National Primate Research Center (WNPRC), Madison, Wisconsin 53715,1 Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 537152

Received 4 April 2008/ Accepted 25 June 2008

The kinetics of peptide presentation by major histocompatibility complex class I (MHC-I) molecules may contribute to the efficacy of CD8+ T cells. Whether all CD8+ T-cell epitopes from a protein are presented by the same MHC-I molecule with similar kinetics is unknown. Here we show that CD8+ T-cell epitopes derived from SIVmac239 Gag are presented with markedly different kinetics. We demonstrate that this discrepancy in presentation is not related to immunodominance but instead is due to differential requirements for epitope generation. These results illustrate that significant differences in presentation kinetics can exist among CD8+ T-cell epitopes derived from the same viral protein.

* Corresponding author. Mailing address: Department of Pathology and Laboratory Medicine, University of Wisconsin—Madison, 555 Science Drive, Madison, WI 53711. Phone: (608) 265-3380. Fax: (608) 265-8084. E-mail: watkins{at}primate.wisc.edu

{triangledown} Published ahead of print on 2 July 2008.

Journal of Virology, September 2008, p. 9293-9298, Vol. 82, No. 18
0022-538X/08/$08.00+0     doi:10.1128/JVI.00749-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Sacha, J. B., Giraldo-Vela, J. P., Buechler, M. B., Martins, M. A., Maness, N. J., Chung, C., Wallace, L. T., Leon, E. J., Friedrich, T. C., Wilson, N. A., Hiraoka, A., Watkins, D. I. (2009). Gag- and Nef-specific CD4+ T cells recognize and inhibit SIV replication in infected macrophages early after infection. Proc. Natl. Acad. Sci. USA 106: 9791-9796 [Abstract] [Full Text]  


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