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Journal of Virology, September 2008, p. 8906-8910, Vol. 82, No. 17
0022-538X/08/$08.00+0     doi:10.1128/JVI.02134-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Neurovirulence of Polytropic Murine Retrovirus Is Influenced by Two Separate Regions on Opposite Sides of the Envelope Protein Receptor Binding Domain{triangledown}

Karin E. Peterson,1* Susan Pourciau,1 Min Du,1 Rachel LaCasse,2 Melissa Pathmajeyan,2 David Poulsen,3 Mavis Agbandje-McKenna,4 Kathy Wehrly,2 and Bruce Chesebro2

Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Skip Bertman Dr., Baton Rouge, Louisiana 70803,1 Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 South 4th St., Hamilton, Montana 59840,2 Department of Biomedical and Pharmaceutical Sciences, Center for Structural and Functional Neuroscience, University of Montana, Missoula, Montana 59801,3 Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida 26104

Received 27 September 2007/ Accepted 30 May 2008

Changes in the envelope proteins of retroviruses can alter the ability of these viruses to infect the central nervous system (CNS) and induce neurological disease. In the present study, nine envelope residues were found to influence neurovirulence of the Friend murine polytropic retrovirus Fr98. When projected on a three-dimensional model, these residues were clustered in two spatially separated groups, one in variable region B of the receptor binding site and the other on the opposite side of the envelope. Further studies indicated a role for these residues in virus replication in the CNS, although the residues did not affect viral entry.

* Corresponding author. Mailing address: Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Skip Bertman Dr., Baton Rouge, LA 70803. Phone: (225) 578-9681. Fax: (225) 578-9701. E-mail: petersonka{at}niaid.nih.gov

{triangledown} Published ahead of print on 25 June 2008.

Journal of Virology, September 2008, p. 8906-8910, Vol. 82, No. 17
0022-538X/08/$08.00+0     doi:10.1128/JVI.02134-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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