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Journal of Virology, September 2008, p. 8882-8886, Vol. 82, No. 17
0022-538X/08/$08.00+0     doi:10.1128/JVI.00920-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Experimental Optic Neuritis Induced by a Demyelinating Strain of Mouse Hepatitis Virus{triangledown}

Kenneth S. Shindler,1 Lawrence C. Kenyon,2 Mahasweta Dutt,1 Susan T. Hingley,3 and Jayasri Das Sarma4*

University of Pennsylvania, Scheie Eye Institute and FM Kirby Center for Molecular Ophthalmology, Philadelphia, Pennsylvania 19104,1 Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107,2 Philadelphia College of Osteopathic Medicine, Philadelphia, Pennsylvania 19131,3 Department of Neurology, Thomas Jefferson University, Philadelphia, Pennsylvania 191074

Received 2 May 2008/ Accepted 18 June 2008

Optic neuritis (ON), an inflammatory demyelinating optic nerve disease, occurs in multiple sclerosis (MS). Pathological mechanisms and potential treatments for ON have been studied via experimental autoimmune MS models. However, evidence suggests that virus-induced inflammation is a likely etiology triggering MS and ON; experimental virus-induced ON models are therefore required. We demonstrate that MHV-A59, a mouse hepatitis virus (MHV) strain that causes brain and spinal cord inflammation and demyelination, induces ON by promoting mixed inflammatory cell infiltration. In contrast, MHV-2, a nondemyelinating MHV strain, does not induce ON. Results reveal a reproducible virus-induced ON model important for the evaluation of novel therapies.

* Corresponding author. Mailing address: 302 JHN, 900 Walnut Street, Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107. Phone: (215) 955-9412. Fax: (215) 503-5848. E-mail: Jayasri.Das-Sarma{at}jefferson.edu

{triangledown} Published ahead of print on 25 June 2008.

Journal of Virology, September 2008, p. 8882-8886, Vol. 82, No. 17
0022-538X/08/$08.00+0     doi:10.1128/JVI.00920-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Das Sarma, J., Kenyon, L. C., Hingley, S. T., Shindler, K. S. (2009). Mechanisms of Primary Axonal Damage in a Viral Model of Multiple Sclerosis. J. Neurosci. 29: 10272-10280 [Abstract] [Full Text]  
  • Roth-Cross, J. K., Stokes, H., Chang, G., Chua, M. M., Thiel, V., Weiss, S. R., Gorbalenya, A. E., Siddell, S. G. (2009). Organ-Specific Attenuation of Murine Hepatitis Virus Strain A59 by Replacement of Catalytic Residues in the Putative Viral Cyclic Phosphodiesterase ns2. J. Virol. 83: 3743-3753 [Abstract] [Full Text]  


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