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Journal of Virology, July 2008, p. 7243-7247, Vol. 82, No. 14
0022-538X/08/$08.00+0     doi:10.1128/JVI.00307-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Rhesus Macaque TRIM5 Alleles Have Divergent Antiretroviral Specificities {triangledown}

Sam J. Wilson,1 Benjamin L. J. Webb,1 Charlotte Maplanka,1 Ruchi M. Newman,2 Ernst J. Verschoor,3 Jonathan L. Heeney,3,4 and Greg J. Towers1*

Medical Research Council Centre for Medical Molecular Virology, Division of Infection and Immunity, University College and Royal Free Medical School, University College London, 46 Cleveland Street, London W1T4JF, United Kingdom,1 Department of Microbiology and Molecular Genetics, Harvard Medical School, Southborough, Massachusetts 01772,2 Department of Virology, Biomedical Primate Research Centre, Rijswijk 288 GJ, The Netherlands,3 Department of Veterinary Medicine—University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom4

Received 12 February 2008/ Accepted 3 May 2008

TRIM5{alpha} is a potent barrier to cross-species retroviral transmission, and TRIM5{alpha}s from different species have divergent antiretroviral specificities. Multiple TRIM5 alleles circulate within rhesus macaque populations. Here we show that they too have different antiretroviral specificities, highlighting how TRIM5 genotypes contribute to protection in an individual or a population.

* Corresponding author. Mailing address: University College London, Medical Research Council Centre for Medical Molecular Virology, 46 Cleveland Street, London W1T 4JF, United Kingdom. Phone: 44-20 7679 9535. Fax: 44-20 7679 9545. E-mail: g.towers{at}ucl.ac.uk

{triangledown} Published ahead of print on 14 May 2008.

Journal of Virology, July 2008, p. 7243-7247, Vol. 82, No. 14
0022-538X/08/$08.00+0     doi:10.1128/JVI.00307-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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