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Journal of Virology, July 2008, p. 6772-6777, Vol. 82, No. 13
0022-538X/08/$08.00+0     doi:10.1128/JVI.00410-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Primate Lentivirus Capsid Sensitivity to TRIM5 Proteins{triangledown}

Zerina Kratovac,1 Cesar A. Virgen,1 Frederick Bibollet-Ruche,2 Beatrice H. Hahn,2 Paul D. Bieniasz,1 and Theodora Hatziioannou1*

Aaron Diamond AIDS Research Center and the Rockefeller University, New York, New York,1 Departments of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama2

Received 25 February 2008/ Accepted 8 April 2008

Mammalian cells express several factors that inhibit lentiviral infection and that have been under strong selective pressure. One of these factors, TRIM5, targets the capsid protein of incoming retrovirus particles and inhibits subsequent steps of the replication cycle. By substituting human immunodeficiency virus type 1 capsid, we were able to show that a set of divergent primate lentivirus capsids was generally not susceptible to restriction by TRIM5 proteins from higher primates. TRIM5{alpha} proteins from other primates exhibited distinct restriction specificities for primate lentivirus capsids. Finally, we identified novel primate lentiviral capsids that are targeted by TRIMCyp proteins.

* Corresponding author. Mailing address: Aaron Diamond AIDS Research Center, 455 1st Avenue, New York, NY 10016. Phone: (212) 448-5091. Fax: (212) 448-5158. E-mail: thatziio{at}adarc.org

{triangledown} Published ahead of print on 16 April 2008.

Journal of Virology, July 2008, p. 6772-6777, Vol. 82, No. 13
0022-538X/08/$08.00+0     doi:10.1128/JVI.00410-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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