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Journal of Virology, June 2008, p. 6052-6055, Vol. 82, No. 12
0022-538X/08/$08.00+0 doi:10.1128/JVI.00297-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Betty Lu,1,
and
David A. Leib1,2*
Departments of Ophthalmology and Visual Sciences,1 Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 631102
Received 10 February 2008/ Accepted 27 March 2008
Mice lacking the Stat1 interferon signaling gene were infected with herpes simplex virus type 1 (HSV-1) or an attenuated recombinant lacking virion host shutoff (
vhs).
vhs virus-infected Stat1–/– mice showed levels of replication equivalent to that of the wild-type virus-infected control mice but reduced relative to wild-type virus-infected Stat1–/– mice. Stat1 deficiency relieves the immunomodulatory deficiency of
vhs virus, but not its inherent growth defect. Also Vhs is dispensable for reactivation.
Published ahead of print on 9 April 2008.
T. J. Pasieka and B. Lu contributed equally to this work.
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