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Journal of Virology, June 2008, p. 6052-6055, Vol. 82, No. 12
0022-538X/08/$08.00+0     doi:10.1128/JVI.00297-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Enhanced Pathogenesis of an Attenuated Herpes Simplex Virus for Mice Lacking Stat1 {triangledown}

Tracy Jo Pasieka,1,{dagger} Betty Lu,1,{dagger} and David A. Leib1,2*

Departments of Ophthalmology and Visual Sciences,1 Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 631102

Received 10 February 2008/ Accepted 27 March 2008

Mice lacking the Stat1 interferon signaling gene were infected with herpes simplex virus type 1 (HSV-1) or an attenuated recombinant lacking virion host shutoff ({Delta}vhs). {Delta}vhs virus-infected Stat1–/– mice showed levels of replication equivalent to that of the wild-type virus-infected control mice but reduced relative to wild-type virus-infected Stat1–/– mice. Stat1 deficiency relieves the immunomodulatory deficiency of {Delta}vhs virus, but not its inherent growth defect. Also Vhs is dispensable for reactivation.

* Corresponding author. Mailing address: Washington University School of Medicine, Department of Ophthalmology and Visual Sciences, 660 South Euclid Ave., Box 8096, St. Louis, MO 63110. Phone: (314) 362-2689. Fax: (314) 362-3638. E-mail: leib{at}vision.wustl.edu

{triangledown} Published ahead of print on 9 April 2008.

{dagger} T. J. Pasieka and B. Lu contributed equally to this work.

Journal of Virology, June 2008, p. 6052-6055, Vol. 82, No. 12
0022-538X/08/$08.00+0     doi:10.1128/JVI.00297-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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