This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Huy, T. T. T.
Right arrow Articles by Abe, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Huy, T. T. T.
Right arrow Articles by Abe, K.

 Previous Article  |  Next Article 

Journal of Virology, June 2008, p. 5657-5663, Vol. 82, No. 11
0022-538X/08/$08.00+0     doi:10.1128/JVI.02556-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

New Complex Recombinant Genotype of Hepatitis B Virus Identified in Vietnam{triangledown}

Tran Thien Tuan Huy,1 Trinh Thi Ngoc,2 and Kenji Abe1*

Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan,1 National Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Hanoi, Vietnam2

Received 30 November 2007/ Accepted 10 March 2008

A novel variant of hepatitis B virus was identified in Vietnam. This strain (HBV-VH24) had a novel intergenotypic recombination between genotypes A, C, and G. VH24 showed high similarity (98.3 to 98.9%) to the "aberrant strains" among Vietnamese isolates reported by Hannoun et al. (C. Hannoun et al., J. Gen. Virol. 81:2267-2272, 2000) and also had similar breakpoints of recombination. Phylogenetic analysis of the complete genome of these strains formed a separate clade. Furthermore, their pre-S/S gene-encoded seven unique conserved amino acid residues were not present in other genotypes. These findings support the designation of the new genotype I.

* Corresponding author. Mailing address: Department of Pathology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan. Phone: (81) 3-5285-1111, ext. 2624. Fax: (81) 3-5285-1189. E-mail: kenjiabe{at}nih.go.jp

{triangledown} Published ahead of print on 19 March 2008.

Journal of Virology, June 2008, p. 5657-5663, Vol. 82, No. 11
0022-538X/08/$08.00+0     doi:10.1128/JVI.02556-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Utsumi, T., Lusida, M. I., Yano, Y., Nugrahaputra, V. E., Amin, M., Juniastuti, , Soetjipto, , Hayashi, Y., Hotta, H. (2009). Complete Genome Sequence and Phylogenetic Relatedness of Hepatitis B Virus Isolates in Papua, Indonesia. J. Clin. Microbiol. 47: 1842-1847 [Abstract] [Full Text]  
  • Fang, Z.-L., Sabin, C. A., Dong, B.-Q., Wei, S.-C., Chen, Q.-Y., Fang, K.-X., Yang, J.-Y., Huang, J., Wang, X.-Y., Harrison, T. J. (2008). Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case-control study. J. Gen. Virol. 89: 2882-2890 [Abstract] [Full Text]  
  • Kurbanov, F., Tanaka, Y., Kramvis, A., Simmonds, P., Mizokami, M. (2008). When Should "I" Consider a New Hepatitis B Virus Genotype?. J. Virol. 82: 8241-8242 [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»