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Journal of Virology, May 2008, p. 5099-5103, Vol. 82, No. 10
0022-538X/08/$08.00+0     doi:10.1128/JVI.01993-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Genomic Analysis of Closely Related Astroviruses{triangledown}

Errol Strain,1 Laura A. Kelley,3 Stacey Schultz-Cherry,4 Spencer V. Muse,1 and Matthew D. Koci2*

Department of Statistics,1 Department of Poultry Science, North Carolina State University, Raleigh, North Carolina 27695,2 Plant Science Research, Biosciences Research Laboratory, USDA-ARS, Fargo, North Dakota 58105,3 Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, Wisconsin 537064

Received 10 September 2007/ Accepted 23 February 2008

To understand astrovirus biology, it is essential to understand factors associated with its evolution. The current study reports the genomic sequences of nine novel turkey astrovirus (TAstV) type 2-like clinical isolates. This represents, to our knowledge, the largest genomic-length data set available for any one astrovirus type. The comparison of these TAstV sequences suggests that the TAstV species contains multiple subtypes and that recombination events have occurred across the astrovirus genome. In addition, the analysis of the capsid gene demonstrated evidence for both site-specific positive selection and purifying selection.

* Corresponding author. Mailing address: Department of Poultry Science, North Carolina State University, Campus Box 7608, Raleigh, NC 27695. Phone: (919) 515-5388. Fax: (919) 515-2625. E-mail: mdkoci{at}ncsu.edu

{triangledown} Published ahead of print on 5 March 2008.

Journal of Virology, May 2008, p. 5099-5103, Vol. 82, No. 10
0022-538X/08/$08.00+0     doi:10.1128/JVI.01993-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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