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Journal of Virology, May 2008, p. 5089-5092, Vol. 82, No. 10
0022-538X/08/$08.00+0     doi:10.1128/JVI.00040-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Role for the L1-52/55K Protein in the Serotype Specificity of Adenovirus DNA Packaging{triangledown}

Beverly P. Wohl and Patrick Hearing*

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, New York 11794

Received 7 January 2008/ Accepted 29 February 2008

The packaging of adenovirus (Ad) DNA into virions is dependent upon cis-acting sequences and trans-acting proteins. We studied the involvement of Ad packaging proteins in the serotype specificity of packaging. Both Ad5 and Ad17 IVa2 and L4-22K proteins complemented the growth of Ad5 IVa2 and L4-22K mutant viruses, respectively. In contrast, the Ad5 L1-52/55K protein complemented an Ad5 L1-52/55K mutant virus, but the Ad17 L1-52/55K protein did not. The analysis of chimeric proteins demonstrated that the N-terminal half of the Ad5 L1-52/55K protein mediated this function. Finally, we demonstrate that the L4-33K and L4-22K proteins have distinct functions during infection.

* Corresponding author. Mailing address: Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794. Phone: (631) 632-8813. Fax: (631) 632-8891. E-mail: phearing{at}ms.cc.sunysb.edu

{triangledown} Published ahead of print on 12 March 2008.

Journal of Virology, May 2008, p. 5089-5092, Vol. 82, No. 10
0022-538X/08/$08.00+0     doi:10.1128/JVI.00040-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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