This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yaiw, K. C.
Right arrow Articles by Thong Wong, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yaiw, K. C.
Right arrow Articles by Thong Wong, K.

 Previous Article  |  Next Article 

Journal of Virology, January 2008, p. 565-568, Vol. 82, No. 1
0022-538X/08/$08.00+0     doi:10.1128/JVI.01660-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Tioman Virus, a Paramyxovirus of Bat Origin, Causes Mild Disease in Pigs and Has a Predilection for Lymphoid Tissues{triangledown}

Koon Chu Yaiw,1,{dagger} John Bingham,2,{dagger} Gary Crameri,2 Bruce Mungall,2 Alex Hyatt,2 Meng Yu,2 Bryan Eaton,2 Devi Shamala,1 Lin-Fa Wang,2 and Kum Thong Wong1*

Department of Pathology and Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia,1 Australian Animal Health Laboratory, Commonwealth Scientific and Industrial Research Organization Livestock Industries, Geelong, Victoria 3220, Australia2

Received 31 July 2007/ Accepted 21 September 2007

Disease manifestation, pathology, and tissue tropism following infection with Tioman virus (TioPV), a newly isolated, bat-derived paramyxovirus, was investigated in subcutaneously (n = 12) and oronasally (n = 4) inoculated pigs. Pigs were either asymptomatic or developed pyrexia, but all of the animals produced neutralizing antibodies. The virus (viral antigen and/or genome) was detected in lymphocytes of the thymus, tonsils, spleen, lymph nodes and Peyer's patches (ileum), tonsillar epithelium, and thymic epithelioreticular cells. Virus was isolated from oral swabs but not from urine. Our findings suggest that the pig could act as an intermediate or amplifying host for TioPV and that oral secretion is a possible means of viral transmission.

* Corresponding author. Mailing address: Department of Pathology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Phone: 60-3-7967 5762. Fax: 60-3-7955 6845. E-mail: wongkt{at}um.edu.my

{triangledown} Published ahead of print on 3 October 2007.

{dagger} K.C.Y. and J.B. contributed equally to this work.

Journal of Virology, January 2008, p. 565-568, Vol. 82, No. 1
0022-538X/08/$08.00+0     doi:10.1128/JVI.01660-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»