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Journal of Virology, May 2007, p. 4904-4908, Vol. 81, No. 9
0022-538X/07/$08.00+0     doi:10.1128/JVI.02509-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Lytic and Latent Antigens of the Human Gammaherpesviruses Kaposi's Sarcoma-Associated Herpesvirus and Epstein-Barr Virus Induce T-Cell Responses with Similar Functional Properties and Memory Phenotypes{triangledown}

Florian Bihl,1 Murli Narayan,2 John V. Chisholm III,1 Leah M. Henry,1 Todd J. Suscovich,1 Elizabeth E. Brown,3 Tania M. Welzel,3 Daniel E. Kaufmann,1 Tauheed M. Zaman,1,4 Sheila Dollard,5 Jeff N. Martin,6 Fred Wang,2 David T. Scadden,7 Kenneth M. Kaye,2 and Christian Brander1*

Partners AIDS Research Center, Massachusetts General Hospital,1 Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts,2 Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland,3 Lemuel Shattuck Hospital, Harvard Medical School, Boston, Massachusetts,4 Centers for Disease Control and Prevention, Atlanta, Georgia,5 Department of Epidemiology and Biostatistics, University of California, San Francisco, California,6 Center for Regenerative Medicine and Technology, Massachusetts General Hospital Cancer Center, Harvard Medical School, and Harvard Stem Cell Institute, Boston, Massachusetts7

Received 14 November 2006/ Accepted 19 February 2007

The cellular immunity against Kaposi's sarcoma-associated herpesvirus (KSHV) is poorly characterized and has not been compared to T-cell responses against other human herpesviruses. Here, novel and dominant targets of KSHV-specific cellular immunity are identified and compared to T cells specific for lytic and latent antigens in a second human gammaherpesvirus, Epstein-Barr virus. The data identify a novel HLA-B57- and HLA-B58-restricted epitope in the Orf57 protein and show consistently close parallels in immune phenotypes and functional response patterns between cells targeting lytic or latent KSHV- and EBV-encoded antigens, suggesting common mechanisms in the induction of these responses.

* Corresponding author. Mailing address: Partners AIDS Research Center, 5th Floor, MGH East, No. 5239, 149 13th Street, Charlestown, MA 02129-2000. Phone: (617) 724 5789. Fax: (617) 726 5411. E-mail: cbrander{at}partners.org

{triangledown} Published ahead of print on 28 February 2007.

Journal of Virology, May 2007, p. 4904-4908, Vol. 81, No. 9
0022-538X/07/$08.00+0     doi:10.1128/JVI.02509-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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