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Journal of Virology, May 2007, p. 4877-4880, Vol. 81, No. 9
0022-538X/07/$08.00+0     doi:10.1128/JVI.02345-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Role of the CD8+ Dendritic Cell Subset in Transmission of Prions{triangledown}

Shneh Sethi,1,{dagger} Kristen M. Kerksiek,2 Thomas Brocker,2 and Hans Kretzschmar1*

Center for Neuropathology and Prion Research,1 Institute of Immunology, Ludwig Maximilians University, München, Germany2

Received 26 October 2006/ Accepted 6 February 2007

Controversial results have been observed in mouse models regarding the role of lymphoid tissues in prion pathogenesis. To investigate the role of dendritic cells (DC), we used a transgenic mouse model. In this model (CD11c-N17Rac1), a significant reduction of CD8+ CD11chi DC has been described, and the remaining CD8+ DC demonstrate a reduced capacity for the uptake of apoptotic cells. After intraperitoneal prion infection, significantly longer incubation times were observed in CD11c-N17Rac1 mice than in controls, indicating that a defect in CD8+ CD11chi DC significantly impedes neuroinvasion after intraperitoneal infection. In contrast, no distinct differences were observed between CD11c-N17Rac1 mice and controls after oral infection. This provides evidence that oral and intraperitoneal prion infections differ in lymphoreticular requirements.

* Corresponding author. Mailing address: Center for Neuropathology and Prion Research, Ludwig Maximilians University, Feodor-Lynen-Strasse 23, 81377 Munich, Germany. Phone: 49 89 2180 78000. Fax: 49 89 2180 78037. E-mail: Hans.Kretzschmar{at}med.uni-muenchen.de

{triangledown} Published ahead of print on 14 February 2007.

{dagger} Current address: Institute of Medical Microbiology and Hygiene, University of Saarland, Homburg/Saar, Germany.

Journal of Virology, May 2007, p. 4877-4880, Vol. 81, No. 9
0022-538X/07/$08.00+0     doi:10.1128/JVI.02345-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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