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Journal of Virology, April 2007, p. 4357-4362, Vol. 81, No. 8
0022-538X/07/$08.00+0     doi:10.1128/JVI.02639-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

New Natural Intergenotypic (2/5) Recombinant of Hepatitis C Virus{triangledown}

Florence Legrand-Abravanel, Julie Claudinon, Florence Nicot, Martine Dubois, Sabine Chapuy-Regaud, Karine Sandres-Saune, Christophe Pasquier, and Jacques Izopet*

Laboratoire de Virologie, Institut Fédératif de Biologie, INSERM U563-IFR30, 330 Avenue de Grande-Bretagne, TSA 40031, 31059 Toulouse Cédex 9, France

Received 29 November 2006/ Accepted 19 January 2007

A 9.2-kb sequence from a hepatitis C virus (HCV) strain found in southwest France was compared to sequences from reference strains in HCV sequence databases. We found a recombinant virus with genotype 2 at the 5' end and genotype 5 at the 3' end. The crossover point was located between genes NS2 and NS3. Recombination between HCV genotypes must now be considered in studies on HCV epidemiology and evolution and in predictions of the virus response to antiviral therapy. Knowing the location of the recombination point may also be useful for constructing infectious chimeric viruses.

* Corresponding author. Mailing address: Laboratoire de Virologie, Institut Fédératif de Biologie, INSERM U563, IFR30, 330 Ave. de Grande-Bretagne, TSA 40031, 31059 Toulouse Cédex 9, France. Phone: (33) 5 67 69 04 24. Fax: (33) 5 67 69 04 25. E-mail: izopet.j{at}chu-toulouse.fr

{triangledown} Published ahead of print on 31 January 2007.

Journal of Virology, April 2007, p. 4357-4362, Vol. 81, No. 8
0022-538X/07/$08.00+0     doi:10.1128/JVI.02639-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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