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Journal of Virology, April 2007, p. 4130-4136, Vol. 81, No. 8
0022-538X/07/$08.00+0     doi:10.1128/JVI.00028-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Identification of a Third Human Polyomavirus{triangledown}

Tobias Allander,1* Kalle Andreasson,2 Shawon Gupta,1 Annelie Bjerkner,1 Gordana Bogdanovic,1,2 Mats A. A. Persson,3 Tina Dalianis,2 Torbjörn Ramqvist,2 and Björn Andersson4

Laboratory for Clinical Microbiology, Department of Microbiology, Tumor and Cell Biology, Karolinska University Hospital, Karolinska Institutet, SE-17176 Stockholm, Sweden,1 Cancer Center Karolinska, Department of Oncology and Pathology, Karolinska University Hospital, Karolinska Institutet, SE-17176 Stockholm, Sweden,2 Center for Molecular Medicine, Department of Medicine, Karolinska University Hospital, Karolinska Institutet, SE-17176 Stockholm, Sweden,3 Department of Cell and Molecular Biology, Karolinska Institutet, SE-17177 Stockholm, Sweden4

Received 5 January 2007/ Accepted 30 January 2007

We have previously reported on a system for large-scale molecular virus screening of clinical samples. As part of an effort to systematically search for unrecognized human pathogens, the technology was applied for virus screening of human respiratory tract samples. This resulted in the identification of a previously unknown polyomavirus provisionally named KI polyomavirus. The virus is phylogenetically related to other primate polyomaviruses in the early region of the genome but has very little homology (<30% amino acid identity) to known polyomaviruses in the late region. The virus was found by PCR in 6 (1%) of 637 nasopharyngeal aspirates and in 1 (0.5%) of 192 fecal samples but was not detected in sets of urine and blood samples. Since polyomaviruses have oncogenic potential and may produce severe disease in immunosuppressed individuals, continued searching for the virus in different medical contexts is important. This finding further illustrates how unbiased screening of respiratory tract samples can be used for the discovery of diverse virus types.

* Corresponding author. Mailing address: Department of Clinical Microbiology, L2:02, Karolinska University Hospital, SE-171 76 Stockholm, Sweden. Phone: 46 8 51773580. Fax: 46 8 308099. E-mail: tobias.allander{at}karolinska.se

{triangledown} Published ahead of print on 7 February 2007.

Journal of Virology, April 2007, p. 4130-4136, Vol. 81, No. 8
0022-538X/07/$08.00+0     doi:10.1128/JVI.00028-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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