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Journal of Virology, April 2007, p. 3769-3777, Vol. 81, No. 8
0022-538X/07/$08.00+0     doi:10.1128/JVI.02728-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Critical Role of Dendritic Cells in Mouse Mammary Tumor Virus In Vivo Infection{triangledown}

Maria Cecilia Courreges,1 Dalia Burzyn,2 Irene Nepomnaschy,2 Isabel Piazzon,2 and Susan R. Ross1*

Department of Microbiology and Abramson Family Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania,1 División Medicina Experimental, Instituto de Investigaciones Hematológicas, Academia Nacional de Medicina de Argentina, Buenos Aires, Argentina2

Received 11 December 2006/ Accepted 23 January 2007

Mouse mammary tumor virus (MMTV) is a milk-transmitted betaretrovirus that causes mammary tumors in mice. Although mammary epithelial cells are the ultimate targets of MMTV, the virus utilizes components of the host immune system to establish infection. Previous studies indicated that dendritic cells play a role in MMTV infection. Here we show that dendritic cells are the first cells to be infected by MMTV in vivo and that they are capable of producing infectious virus that can be transmitted to other cell types. Moreover, upon contact with the virus, dendritic cells became more mature and migrated in response to the chemokine macrophage inflammatory protein 3ß. Finally, we demonstrate that targeted ablation of dendritic cells in vivo dramatically attenuated MMTV infection. These data indicate that MMTV infection of dendritic cells is critical to initial propagation of the virus in vivo.

* Corresponding author. Mailing address: University of Pennsylvania, 313 BRBII/III, 421 Curie Blvd., Philadelphia, PA 19104-6142. Phone: (215) 898-9764. Fax: (215) 573-2028. E-mail: rosss{at}mail.med.upenn.edu

{triangledown} Published ahead of print on 31 January 2007.

Journal of Virology, April 2007, p. 3769-3777, Vol. 81, No. 8
0022-538X/07/$08.00+0     doi:10.1128/JVI.02728-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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