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Journal of Virology, April 2007, p. 3667-3672, Vol. 81, No. 7
0022-538X/07/$08.00+0     doi:10.1128/JVI.02689-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8+ T-Cell Epitopes{triangledown}

Isobella Honeyborne,1 Andrew Prendergast,1 Florencia Pereyra,2 Alasdair Leslie,1 Hayley Crawford,1 Rebecca Payne,1 Shabashini Reddy,3 Karen Bishop,3 Eshia Moodley,3 Kriebashnie Nair,3 Mary van der Stok,3 Noel McCarthy,4 Christine M. Rousseau,5 Marylyn Addo,2 James I. Mullins,5 Christian Brander,2 Photini Kiepiela,3 Bruce D. Walker,2 and Philip J. R. Goulder1,2,3*

Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom,1 Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129,2 HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban 4013, South Africa,3 Department of Zoology, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom,4 Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-80705

Received 6 December 2006/ Accepted 16 January 2007

To better understand relationships between CD8+ T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with low viremia, in a cohort of 578 C clade-infected individuals in Durban, South Africa. Six novel B*13-restricted cytotoxic T lymphocyte epitopes were defined from analyses of 37 B*13-positive subjects, including three Gag epitopes. These B*13-restricted epitopes contribute to a broad Gag-specific CD8+ response that is associated with the control of viremia. These data are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia.

* Corresponding author. Mailing address: Peter Medawar Bldg. for Pathogen Research, South Parks Rd., Oxford OX1 3SY, United Kingdom. Phone: 44-1865-281884. Fax: 44-1865-281890. E-mail: philip.goulder{at}ndm.ox.ac.uk.

{triangledown} Published ahead of print on 24 January 2007.

Journal of Virology, April 2007, p. 3667-3672, Vol. 81, No. 7
0022-538X/07/$08.00+0     doi:10.1128/JVI.02689-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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