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Journal of Virology, April 2007, p. 3667-3672, Vol. 81, No. 7
0022-538X/07/$08.00+0     doi:10.1128/JVI.02689-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8⁺ T-Cell Epitopes

Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom,¹ Partners AIDS Research Center and Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129,² HIV Pathogenesis Programme, Doris Duke Medical Research Institute, University of KwaZuluNatal, Durban 4013, South Africa,³ Department of Zoology, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom,⁴ Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195-8070⁵

Received 6 December 2006/ Accepted 16 January 2007

To better understand relationships between CD8⁺ T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with low viremia, in a cohort of 578 C clade-infected individuals in Durban, South Africa. Six novel B*13-restricted cytotoxic T lymphocyte epitopes were defined from analyses of 37 B*13-positive subjects, including three Gag epitopes. These B*13-restricted epitopes contribute to a broad Gag-specific CD8⁺ response that is associated with the control of viremia. These data are consistent with data from studies of other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia.

Published ahead of print on 24 January 2007.

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