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Journal of Virology, April 2007, p. 3640-3644, Vol. 81, No. 7
0022-538X/07/$08.00+0     doi:10.1128/JVI.02254-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Direct Visualization of the Putative Portal in the Kaposi's Sarcoma-Associated Herpesvirus Capsid by Cryoelectron Tomography{triangledown} ,{dagger}

Binbin Deng,1,2 Christine M. O'Connor,3 Dean H. Kedes,3,4 and Z. Hong Zhou1,2*

Department of Pathology and Laboratory Medicine,1 Keck Center Pharmacoinformatics Training Program of the Gulf Coast Consortia, University of Texas Medical School at Houston, 6431 Fannin, Houston, Texas 77030,2 Myles H. Thaler Center for AIDS and Human Retrovirus Research, Department of Microbiology,3 Department of Medicine, University of Virginia, Charlottesville, Virginia 229084

Received 14 October 2006/ Accepted 28 December 2006

Genetic and biochemical studies have suggested the existence of a bacteriophage-like, DNA-packaging/ejecting portal complex in herpesviruses capsids, but its arrangement remained unknown. Here, we report the first visualization of a unique vertex in the Kaposi's sarcoma-associated herpesvirus (KSHV) capsid by cryoelectron tomography, thus providing direct structural evidence for the existence of a portal complex in a gammaherpesvirus. This putative KSHV portal is an internally localized, umbilicated structure and lacks all of the external machineries characteristic of portals in DNA bacteriophages.

* Corresponding author. Mailing address: Department of Pathology and Laboratory Medicine, University of Texas Medical School at Houston, 6431 Fannin St., MSB 2.280, Houston, TX 77030. Phone: (713) 500-5358. Fax: (713) 500-0730. E-mail: z.h.zhou{at}uth.tmc.edu.

{triangledown} Published ahead of print on 10 January 2007.

{dagger} Supplemental material for this article may be found at http://jvi.asm.org.

Journal of Virology, April 2007, p. 3640-3644, Vol. 81, No. 7
0022-538X/07/$08.00+0     doi:10.1128/JVI.02254-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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