This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Labadie, K.
Right arrow Articles by Colbère-Garapin, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Labadie, K.
Right arrow Articles by Colbère-Garapin, F.

 Previous Article  |  Next Article 

Journal of Virology, March 2007, p. 3033-3036, Vol. 81, No. 6
0022-538X/07/$08.00+0     doi:10.1128/JVI.01960-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Reduced Apoptosis in Human Intestinal Cells Cured of Persistent Poliovirus Infection{triangledown}

Karine Labadie,{dagger} Aure Saulnier,{dagger} Sandra Martin-Latil, and Florence Colbère-Garapin*

Virus Entérotropes et Stratégies Antivirales, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France

Received 8 September 2006/ Accepted 18 December 2006

Cells cured of persistent virus infection can be used to investigate cellular pathways of resistance to viral cytopathic effects. Persistent poliovirus (PV) infections were established in human intestinal Caco-2 cells, and spontaneously cured cell cultures were obtained. Two cell clones, cl6 and b13, cured of type 3 PV mutant infection and their parental Caco-2 cells were compared for susceptibility to PV infection, PV receptor CD155 expression, capacity to differentiate into polarized enterocytes, and PV-, staurosporine-, and actinomycin D-induced apoptosis. Our results strongly suggest that cells that are partially resistant to apoptosis can be selected during persistent virus infection.

* Corresponding author. Mailing address: Virus Entérotropes et Stratégies Antivirales, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: (33) 1 45 68 87 64. Fax: (33) 1 40 61 33 67. E-mail: fcolbere{at}pasteur.fr.

{triangledown} Published ahead of print on 27 December 2006.

{dagger} Present address: Génétique Moléculaire des Virus Respiratoires, Institut Pasteur, Paris, France.

Journal of Virology, March 2007, p. 3033-3036, Vol. 81, No. 6
0022-538X/07/$08.00+0     doi:10.1128/JVI.01960-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»