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Journal of Virology, March 2007, p. 2531-2534, Vol. 81, No. 5
0022-538X/07/$08.00+0     doi:10.1128/JVI.02169-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Declining Growth Rate of West Nile Virus in North America{triangledown}

Katherine W. Snapinn,1 Edward C. Holmes,1,2* David S. Young,3 Kristen A. Bernard,3,4 Laura D. Kramer,3,4 and Gregory D. Ebel5

Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802,1 Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892,2 The Arbovirus Laboratories, Wadsworth Center, New York State Department of Health, 5668 State Farm Rd., Slingerlands, New York 12159,3 Department of Biomedical Sciences, School of Public Health, The University at Albany, State University of New York, Albany, New York 12144-3456,4 Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico 871315

Received 3 October 2006/ Accepted 6 December 2006

To determine the demographic history of West Nile virus (WNV) in North America, we employed a coalescent method to envelope coding region data sets for the NY99 and WN02 genotypes. Although the observed genetic diversities in both genotypes were of approximately the same age, the mean rate of epidemiological growth of the WN02 population was approximately three times that of the NY99 population, a finding compatible with the recent dominance of the former genotype. However, there has also been a marked decrease in the recent growth rate of WN02, suggesting that WNV has reached its peak prevalence in North America.

* Corresponding author. Mailing address: Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, Mueller Laboratory, University Park, PA 16802. Phone: (814) 863-4689. Fax: (814) 865-9131. E-mail: ech15{at}psu.edu.

{triangledown} Published ahead of print on 20 December 2006.

Journal of Virology, March 2007, p. 2531-2534, Vol. 81, No. 5
0022-538X/07/$08.00+0     doi:10.1128/JVI.02169-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Vanlandingham, D. L., McGee, C. E., Klingler, K. A., Galbraith, S. E., Barrett, A. D. T., Higgs, S. (2008). Comparison of Oral Infectious Dose of West Nile Virus Isolates Representing Three Distinct Genotypes in Culex quinquefasciatus. Am J Trop Med Hyg 79: 951-954 [Abstract] [Full Text]  
  • Moudy, R. M., Meola, M. A., Morin, L.-L. L., Ebel, G. D., Kramer, L. D. (2007). A Newly Emergent Genotype of West Nile Virus Is Transmitted Earlier and More Efficiently by Culex Mosquitoes. Am J Trop Med Hyg 77: 365-370 [Abstract] [Full Text]  


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