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Journal of Virology, February 2007, p. 1528-1533, Vol. 81, No. 3
0022-538X/07/$08.00+0     doi:10.1128/JVI.01596-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

A Single-Nucleotide Synonymous Mutation in the gag Gene Controlling Human Immunodeficiency Virus Type 1 Virion Production{triangledown}

Takaichi Hamano,1 Kazuhiro Matsuo,1 Yurina Hibi,2 Ann Florence B. Victoriano,2 Naoko Takahashi,2 Yosio Mabuchi,3 Tsuyoshi Soji,3 Shinji Irie,4 Pathom Sawanpanyalert,5 Hideki Yanai,6 Takashi Hara,1 Shudo Yamazaki,1 Naoki Yamamoto,1 and Takashi Okamoto2*

National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan,1 Departments of Molecular and Cellular Biology,2 Functional Morphology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan,3 International Laboratory of Advanced Molecular Medicine Incorporated, Level 16, Shiroyama Hills, 4-3-1 Toranomon, Minato-ku, Tokyo 105-6016, Japan,4 National Institute of Health, Ministry of Public Health, 88/7 Soi Bamrasnaradura, Tivanond Road, Nonthaburi 11000, Thailand,5 TB/HIV Research Project, RIT-JATA, 1050 Satarn Payabarn Road, Muang District, Chiang Rai 57000, Thailand6

Received 26 July 2006/ Accepted 5 November 2006

Viral factors as well as host ones play major roles in the disease progression of human immunodeficiency virus type 1 (HIV-1) infection. We have examined cytotoxic T-lymphocyte activity and HIV-1 DNA PCR results of 312 high-risk seronegative drug users in northern Thailand and identified four seronegative cases positive for both assays. Furthermore, we have identified a synonymous mutation in nucleotide position 75 of the gag p17 gene (A426G) of HIV-1 that belongs to the CRF01_AE virus circulating in Thailand. The replication-competent HIV-1 clone containing the A426G mutation demonstrated a dramatic reduction of virion production and perturbation of viral morphogenesis without affecting viral protein synthesis in cells.

* Corresponding author. Mailing address: Department of Molecular and Cellular Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan. Phone: 81 52 853 8205. Fax: 81 52 859 1235. E-mail: tokamoto{at}med.nagoya-cu.ac.jp.

{triangledown} Published ahead of print on 22 November 2006.

Journal of Virology, February 2007, p. 1528-1533, Vol. 81, No. 3
0022-538X/07/$08.00+0     doi:10.1128/JVI.01596-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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