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Journal of Virology, February 2007, p. 1511-1516, Vol. 81, No. 3
0022-538X/07/$08.00+0     doi:10.1128/JVI.01816-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Latent Protein LANA2 from Kaposi's Sarcoma-Associated Herpesvirus Interacts with 14-3-3 Proteins and Inhibits FOXO3a Transcription Factor{triangledown}

Cesar Muñoz-Fontela,1 Laura Marcos-Villar,1 Pedro Gallego,1 Javier Arroyo,1 Marco Da Costa,2 Karen M. Pomeranz,2 Eric W.-F. Lam,2 and Carmen Rivas1*

Microbiología II, Fac Farmacia, UCM, Madrid, Spain,1 Cancer Research-UK Laboratories and Department of Oncology, Imperial College London, London, United Kingdom2

Received 21 August 2006/ Accepted 5 November 2006

The Kaposi's sarcoma-associated herpesvirus latent protein LANA2 has been suggested to have an important role in the transforming activity of the virus based on its capacity to inhibit p53 and PKR-dependent apoptosis as well as the interferon-dependent response. Here, we describe a novel interaction between LANA2 and both the phosphoserine/phosphothreonine-binding 14-3-3 proteins and the transcription factor FOXO3a. In addition, our results indicate that LANA2 inhibits the transcriptional activity of FOXO3a and blocks the G2/M arrest induced by 14-3-3 protein overexpression. These results suggest a novel mechanism by which LANA2 may promote tumorigenesis.

* Corresponding author. Mailing address: Microbiologia II, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain. Phone: 34 91 3941746. Fax: 34 91 3941745. E-mail: mdcrivas{at}farm.ucm.es.

{triangledown} Published ahead of print on 15 November 2006.

Journal of Virology, February 2007, p. 1511-1516, Vol. 81, No. 3
0022-538X/07/$08.00+0     doi:10.1128/JVI.01816-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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