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Journal of Virology, December 2007, p. 13456-13468, Vol. 81, No. 24
0022-538X/07/$08.00+0     doi:10.1128/JVI.01619-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Dynamics of T-Cell Responses and Memory T Cells during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques{triangledown}

Ingrid Karlsson,1 Benoît Malleret,1 Patricia Brochard,1 Benoît Delache,1 Julien Calvo,1 Roger Le Grand,1,2 and Bruno Vaslin1,2*

CEA, Service d'Immuno-Virologie, DSV/iMETI, IPSC, Fontenay-aux-Roses, France,1 Université Paris XI, UMRE01, Orsay, France2

Received 25 July 2007/ Accepted 26 September 2007

Cellular immune responses make an important contribution to both the control of human immunodeficiency virus (HIV) replication and disease progression. We used a pathogenic model of SIVmac251 infection of cynomolgus macaques to longitudinally evaluate cellular immune responses in association with various rates of disease progression. We found an inverse relationship between plasma viral load and the simian immunodeficiency virus (SIV)-specific T cells responses in peripheral blood and lymph nodes. SIV-specific T-cell responses in peripheral blood were transient during primary infection, with the highest responses detected around 3 months after infection. There was also a transient increase of central memory CD8+ T cells in peripheral blood during primary infection, and effector memory T-cell counts in peripheral lymph nodes were increased. This study emphasizes the importance of the early virus-specific immune responses in the outcome of HIV/SIV disease and provides details about the changes of virus-specific immune responses over time.

* Corresponding author. Mailing address: CEA, Service d'Immuno-Virologie, DSV/iMETI, 18 Route du Panorama, BP 6, 92 265 Fontenay-aux-Roses, France. Phone: 33 1 46 54 94 78. Fax: 33 1 46 54 77 26. E-mail: bruno.vaslin{at}cea.fr

{triangledown} Published ahead of print on 3 October 2007.

Journal of Virology, December 2007, p. 13456-13468, Vol. 81, No. 24
0022-538X/07/$08.00+0     doi:10.1128/JVI.01619-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Malleret, B., Maneglier, B., Karlsson, I., Lebon, P., Nascimbeni, M., Perie, L., Brochard, P., Delache, B., Calvo, J., Andrieu, T., Spreux-Varoquaux, O., Hosmalin, A., Le Grand, R., Vaslin, B. (2008). Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I interferon, and immune suppression. Blood 112: 4598-4608 [Abstract] [Full Text]  


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