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Journal of Virology, December 2007, p. 13291-13298, Vol. 81, No. 24
0022-538X/07/$08.00+0     doi:10.1128/JVI.01580-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Antiviral Antibodies Are Necessary To Prevent Cytotoxic T-Lymphocyte Escape in Mice Infected with a Coronavirus{triangledown}

Noah S. Butler,1 Ajai A. Dandekar,1,{dagger} and Stanley Perlman1,2*

Program in Immunology,1 Department of Microbiology, University of Iowa; Iowa City, Iowa 522422

Received 19 July 2007/ Accepted 25 September 2007

Mutation within virus-derived CD8 T-cell epitopes can effectively abrogate cytotoxic T-lymphocyte (CTL) recognition and impede virus clearance in infected hosts. These so-called "CTL escape variant viruses" are commonly selected during persistent infections and are associated with rapid disease progression and increased disease severity. Herein, we tested whether antiviral antibody-mediated suppression of virus replication and subsequent virus clearance were necessary for preventing CTL escape in coronavirus-infected mice. We found that compared to wild-type mice, B-cell-deficient mice did not efficiently clear infectious virus, uniformly developed clinical disease, and harbored CTL escape variant viruses. These data directly demonstrate a critical role for antiviral antibody in protecting from the selective outgrowth of CTL escape variant viruses.

* Corresponding author. Mailing address: Department of Microbiology, University of Iowa, Iowa City, IA 52242. Phone: (319) 335-8549. Fax: (319) 335-9999. E-mail: Stanley-perlman{at}uiowa.edu

{triangledown} Published ahead of print on 3 October 2007.

{dagger} Present address: Department of Internal Medicine, University of Washington, Seattle, WA 98195.

Journal of Virology, December 2007, p. 13291-13298, Vol. 81, No. 24
0022-538X/07/$08.00+0     doi:10.1128/JVI.01580-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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