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Journal of Virology, December 2007, p. 13242-13247, Vol. 81, No. 23
0022-538X/07/$08.00+0     doi:10.1128/JVI.01396-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Acetylated Histone H3 and H4 Mark the Upregulated LMP2A Promoter of Epstein-Barr Virus in Lymphoid Cells{triangledown}

Borbala Gerle,1,{dagger} Anita Koroknai,1,{dagger} György Fejer,2,{dagger} Agnes Bakos,1 Ferenc Banati,1 Kalman Szenthe,1 Hans Wolf,3 Hans Helmut Niller,3 Janos Minarovits,1 and Daniel Salamon1*

Microbiological Research Group, National Center for Epidemiology, Pihenö u. 1, H-1529 Budapest, Hungary,1 Max-Planck Institut für Immunbiologie, Stübeweg 51, D-79108 Freiburg,2 Department of Microbiology and Hygiene, University of Regensburg, Franz-Josef-Strauss Allee 11, D-93053 Regensburg, Germany3

Received 26 June 2007/ Accepted 31 August 2007

We analyzed the levels of acetylated histones and histone H3 dimethylated on lysine 4 (H3K4me2) at the LMP2A promoter (LMP2Ap) of Epstein-Barr virus in well-characterized type I and type III lymphoid cell line pairs and additionally in the nasopharyngeal carcinoma cell line C666-1 by using chromatin immunoprecipitation. We found that enhanced levels of acetylated histones marked the upregulated LMP2Ap in lymphoid cells. In contrast, in C666-1 cells, the highly DNA-methylated, inactive LMP2Ap was also enriched in acetylated histones and H3K4me2. Our results suggest that the combinatorial effects of DNA methylation, histone acetylation, and H3K4me2 modulate the activity of LMP2Ap.

* Corresponding author. Mailing address: Microbiological Research Group, National Center for Epidemiology, Pihenö u. 1, H-1529 Budapest, Hungary. Phone: 36-1-394-5044. Fax: 36-1-394-5409. E-mail: saladili{at}yahoo.com

{triangledown} Published ahead of print on 26 September 2007.

{dagger} These authors contributed equally to the work.

Journal of Virology, December 2007, p. 13242-13247, Vol. 81, No. 23
0022-538X/07/$08.00+0     doi:10.1128/JVI.01396-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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