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Journal of Virology, November 2007, p. 12709-12714, Vol. 81, No. 22
0022-538X/07/$08.00+0     doi:10.1128/JVI.01406-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Isolation of Avian Paramyxovirus 1 from a Patient with a Lethal Case of Pneumonia{triangledown}

Scott J. Goebel,1 Jill Taylor,1 Bradd C. Barr,2 Timothy E. Kiehn,3 Hugo R. Castro-Malaspina,3 Cyrus V. Hedvat,3 Kim A. Rush-Wilson,1 Cassandra D. Kelly,1 Stephen W. Davis,1 William A. Samsonoff,1 Kelley R. Hurst,1 Melissa J. Behr,1 and Paul S. Masters1*

Divisions of Infectious Disease and Molecular Medicine, Wadsworth Center, New York State Department of Health, Albany, New York 12201,1 California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California, Davis, California 95616,2 Departments of Clinical Laboratories, Medicine, and Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 100213

Received 27 June 2007/ Accepted 4 September 2007

An unknown virus was isolated from a lung biopsy sample and multiple other samples from a patient who developed a lethal case of pneumonia following a peripheral blood stem cell transplant. A random PCR-based molecular screening method was used to identify the infectious agent as avian paramyxovirus 1 (APMV-1; a group encompassing Newcastle disease virus), which is a highly contagious poultry pathogen that has only rarely been found in human infections. Immunohistochemical analysis confirmed the presence of APMV-1 antigen in sloughed alveolar cells in lung tissue from autopsy. Sequence from the human isolate showed that it was most closely related to virulent pigeon strains of APMV-1. This is the most completely documented case of a systemic human infection caused by APMV-1 and is the first report of an association between this virus and a fatal disease in a human.

* Corresponding author. Mailing address: David Axelrod Institute, Wadsworth Center, NYSDOH, New Scotland Avenue, P.O. Box 22002, Albany, NY 12201-2002. Phone: (518) 474-1283. Fax: (518) 473-1326. E-mail: masters{at}wadsworth.org

{triangledown} Published ahead of print on 12 September 2007.

Journal of Virology, November 2007, p. 12709-12714, Vol. 81, No. 22
0022-538X/07/$08.00+0     doi:10.1128/JVI.01406-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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