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Differential Inhibition of Type I Interferon Induction by Arenavirus Nucleoproteins

Department of Microbiology,¹ Emerging Pathogens Institute,² Microbiology Graduate Training Program, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, New York 10029,³ Molecular Integrative Neuroscience Department (MIND), The Scripps Research Institute, La Jolla, California 92037⁴

Received 24 April 2007/ Accepted 27 August 2007

We have documented that the nucleoprotein (NP) of the prototypic arenavirus lymphocytic choriomeningitis virus is an antagonist of the type I interferon response. In this study we tested the ability of NPs encoded by representative arenavirus species from both Old World and New World antigenic groups to inhibit production of interferon. We found that, with the exception of Tacaribe virus (TCRV), all NPs tested inhibited activation of beta interferon and interferon regulatory factor 3 (IRF-3)-dependent promoters, as well as the nuclear translocation of IRF-3. Consistent with this observation, TCRV-infected cells also failed to inhibit interferon production.

Published ahead of print on 5 September 2007.