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Journal of Virology, November 2007, p. 12670-12674, Vol. 81, No. 22
0022-538X/07/$08.00+0     doi:10.1128/JVI.00476-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Interleukin-7 Enhances Proliferation Responses to T-Cell Receptor Stimulation in Naïve CD4+ T Cells from Human Immunodeficiency Virus-Infected Persons{triangledown}

Douglas A. Bazdar and Scott F. Sieg*

Department of Medicine, Division of Infectious Diseases, Center for AIDS Research, Case Western Reserve University, Cleveland, Ohio 44106

Received 6 March 2007/ Accepted 1 September 2007

Proliferation responses of naïve CD4+ T cells to T-cell receptor and interleukin-7 (IL-7) stimulation were evaluated by using cells from human immunodeficiency virus-positive (HIV+) donors. IL-7 enhanced responses to T-cell receptor stimulation, and the magnitude of this enhancement was similar in cells from healthy controls and from HIV+ subjects. The overall response to T-cell receptor stimulation alone or in combination with IL-7, however, was diminished among viremic HIV+ donors and occurred independent of antigen-presenting cells. Frequencies of CD127+ cells were related to the magnitudes of proliferation enhancement that were mediated by IL-7. Thus, IL-7 enhances but does not fully restore the function of naïve CD4+ T cells from HIV-infected persons.

* Corresponding author. Mailing address: Case Western Reserve University, BRB, Rm. 1020, 2109 Adelbert Road, Cleveland, OH 44106. Phone: (216) 368-6594. Fax: (216) 368-5415. E-mail: scott.sieg{at}case.edu

{triangledown} Published ahead of print on 12 September 2007.

Journal of Virology, November 2007, p. 12670-12674, Vol. 81, No. 22
0022-538X/07/$08.00+0     doi:10.1128/JVI.00476-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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