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 Previous Article

Journal of Virology, November 2007, p. 12097-12100, Vol. 81, No. 21
0022-538X/07/$08.00+0     doi:10.1128/JVI.01216-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Activation of Phosphatidylinositol 3-Kinase Signaling by the Nonstructural NS1 Protein Is Not Conserved among Type A and B Influenza Viruses{triangledown}

Christina Ehrhardt,1 Thorsten Wolff,2 and Stephan Ludwig1*

Institute of Molecular Virology (IMV), ZMBE, Westfaelische-Wilhelms-University, Von Esmarch-Str. 56, D-48149 Muenster, Germany,1 Robert-Koch-Institute, P15, Nordufer 20, D-13353 Berlin, Germany2

Received 4 June 2007/ Accepted 14 August 2007

Recently it has been shown by several laboratories that the influenza A virus nonstructural protein 1 (A/NS1) binds and activates phosphatidylinositol 3-kinase (PI3K). This function of the protein is likely to prevent premature apoptosis induction during viral propagation. Here we show that the B/NS1 protein completely lacks the capacity to induce PI3K signaling. Thus, PI3K activation is another unique function of A/NS1 that is different from the action of its influenza B virus counterpart.

* Corresponding author. Mailing address: Institute of Molecular Virology (IMV), ZMBE, Westfaelische-Wilhelms-University, Von Esmarch-Str. 56, D-48149 Muenster, Germany. Phone: 49 251 83 57791. Fax: 49 251 83 57793. E-mail: ludwigs{at}uni-muenster.de

{triangledown} Published ahead of print on 22 August 2007.

Journal of Virology, November 2007, p. 12097-12100, Vol. 81, No. 21
0022-538X/07/$08.00+0     doi:10.1128/JVI.01216-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Xing, Z., Cardona, C. J., Adams, S., Yang, Z., Li, J., Perez, D., Woolcock, P. R. (2009). Differential regulation of antiviral and proinflammatory cytokines and suppression of Fas-mediated apoptosis by NS1 of H9N2 avian influenza virus in chicken macrophages. J. Gen. Virol. 90: 1109-1118 [Abstract] [Full Text]  


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