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Journal of Virology, November 2007, p. 12086-12090, Vol. 81, No. 21
0022-538X/07/$08.00+0     doi:10.1128/JVI.00800-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Identification of an Arsenic-Sensitive Block to Primate Lentiviral Infection of Human Dendritic Cells{triangledown}

Marjorie Pion,1 Romaine Stalder,1 Rafael Correa,1 Bastien Mangeat,1 Greg J. Towers,2 and Vincent Piguet1*

Departments of Dermatology and Venereology and of Microbiology and Molecular Medicine, University Hospital and Medical School of Geneva, Geneva, Switzerland,1 MRC Centre for Medical Molecular Virology, Department of Infection, Royal Free and University College Medical School, UCL, London W1T4JF, United Kingdom2

Received 13 April 2007/ Accepted 18 August 2007

Dendritic cells are central to the early events of human immunodeficiency virus type 1 (HIV-1) transmission, but HIV-1 infects dendritic cells inefficiently in vitro compared to activated CD4+ T cells. There is a strong postentry restriction of HIV-1 infection in dendritic cells, partly mediated by the cellular restriction factor APOBEC3G. Here, we reveal that arsenic trioxide markedly increases HIV infection of immature and mature dendritic cells as well as blood-derived myeloid dendritic cells in an APOBEC3G- and TRIM5{alpha}-independent way. Our data suggest the presence of powerful, arsenic-sensitive antiviral activities in primary human immune cells of the dendritic cell lineage.

* Corresponding author. Mailing address: Department of Dermatology and Venereology, Department of Microbiology and Molecular Medicine, University Hospital and Medical School of Geneva, 4-712, 24 Rue Micheli-du-Crest, 1211 Geneva, Switzerland. Phone: (4122) 372.94.65. Fax: (4122) 372.94.70. E-mail: vincent.piguet{at}medecine.unige.ch

{triangledown} Published ahead of print on 29 August 2007.

Journal of Virology, November 2007, p. 12086-12090, Vol. 81, No. 21
0022-538X/07/$08.00+0     doi:10.1128/JVI.00800-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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