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Journal of Virology, November 2007, p. 12080-12085, Vol. 81, No. 21
0022-538X/07/$08.00+0     doi:10.1128/JVI.00815-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

The Transcription Profile of the Bocavirus Bovine Parvovirus Is Unlike Those of Previously Characterized Parvoviruses

Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas,¹ Department of Microbiology and Molecular Biology, Brigham Young University, Provo, Utah,² Department of Molecular Microbiology and Immunology, Life Sciences Center, University of Missouri-Columbia, Columbia, Missouri³

Received 16 April 2007/ Accepted 13 August 2007

The Bocavirus bovine parvovirus generated a single pre-mRNA from a promoter at its left-hand end; however, the pattern of its alternative polyadenylation and splicing was different from that of other parvoviruses. A large left-hand-end open reading frame (ORF) encoded a nonstructural protein of approximately 95 kDa. An abundant, spliced, internally polyadenylated transcript encoded the viral NP1 protein from an ORF in the center of the genome. Transcripts encoding the capsid proteins were polyadenylated in the right-hand terminal palindrome. This is the first published transcription map of a member of the Bocavirus genus of the Parvovirinae.

Published ahead of print on 22 August 2007.