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Journal of Virology, November 2007, p. 12066-12070, Vol. 81, No. 21
0022-538X/07/$08.00+0     doi:10.1128/JVI.00818-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Disease Duration Determines Canine Distemper Virus Neurovirulence{triangledown}

François Bonami, Penny A. Rudd, and Veronika von Messling*

INRS-Institut Armand-Frappier, University of Quebec, Laval, Quebec, Canada

Received 16 April 2007/ Accepted 6 August 2007

The Morbillivirus hemagglutinin (H) protein mediates attachment to the target cell. To evaluate its contribution to canine distemper virus neurovirulence, we exchanged the H proteins of the wild-type strains 5804P and A75 and assessed the pathogenesis of the chimeric viruses in ferrets. Both strains are lethal to ferrets; however, 5804P causes a 2-week disease without neurological signs, whereas A75 is associated with a longer disease course and neurological involvement. We observed that both H proteins supported neuroinvasion and the subsequent development of clinical neurological signs if given enough time, demonstrating that disease duration is the main neurovirulence determinant.

* Corresponding author. Mailing address: INRS-Institut Armand-Frappier, University of Quebec, 531, boul. des Prairies, Laval, Quebec H7V 1B7, Canada. Phone: (450) 687-5010. Fax: (450) 686-5305. E-mail: veronika.vonmessling{at}iaf.inrs.ca

{triangledown} Published ahead of print on 15 August 2007.

Journal of Virology, November 2007, p. 12066-12070, Vol. 81, No. 21
0022-538X/07/$08.00+0     doi:10.1128/JVI.00818-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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