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Journal of Virology, October 2007, p. 11538-11542, Vol. 81, No. 20
0022-538X/07/$08.00+0     doi:10.1128/JVI.00581-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Symptomatic and Asymptomatic Viral Recrudescence in Solid-Organ Transplant Recipients and Its Relationship with the Antigen-Specific CD8+ T-Cell Response{triangledown}

Tania Crough,1,2 Chrysa Fazou,1 Julissa Weiss,1 Scott Campbell,3 Miles P. Davenport,4 Scott C. Bell,5 Andrew Galbraith,5 Keith McNeil,5 and Rajiv Khanna1*

Australian Centre for Vaccine Development and Tumour Immunology Laboratory, Division of Infectious Diseases and Immunology, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, Queensland 4029, Australia,1 School of Medicine, University of Queensland, Brisbane, Queensland, Australia,2 Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington 2052, Australia,4 The Prince Charles Hospital, Rode Road, Chermside, and Department of Medicine, University of Queensland, Brisbane, Queensland, Australia,5 Department of Nephrology, Princess Alexandra Hospital, and Department of Medicine, University of Queensland, Brisbane, Queensland, Australia3

Received 19 March 2007/ Accepted 26 July 2007

Using ex vivo antigen-specific T-cell analysis, we found that symptomatic cytomegalovirus recrudescence in transplant recipients was coincident with reduced expression of gamma interferon (IFN-{gamma}) by virus-specific CD8+ T cells and an up-regulation of CD38 expression on these T cells, although there was no significant change in the absolute number of virus-specific cells (as assessed by major histocompatibility complex-peptide multimers). In contrast, HLA class I-matched transplant patients with asymptomatic viral recrudescence showed increased expansion of antigen-specific T cells and highly stable IFN-{gamma} expression by epitope-specific T cells. These studies suggest that a strong functional T-cell response plays a crucial role in defining the clinical outcome of acute viral recrudescence.


* Corresponding author. Mailing address: Queensland Institute of Medical Research, Bancroft Centre, 300 Herston Rd., Brisbane, Australia 4029. Phone: 61-7-3362 0385. Fax: 61-7-3845 3510. E-mail: rajiv.khanna{at}qimr.edu.au

{triangledown} Published ahead of print on 8 August 2007.


Journal of Virology, October 2007, p. 11538-11542, Vol. 81, No. 20
0022-538X/07/$08.00+0     doi:10.1128/JVI.00581-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.







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