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Journal of Virology, January 2007, p. 568-574, Vol. 81, No. 2
0022-538X/07/$08.00+0     doi:10.1128/JVI.01512-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Mouse Hepatitis Virus Does Not Induce Beta Interferon Synthesis and Does Not Inhibit Its Induction by Double-Stranded RNA{triangledown}

Haixia Zhou and Stanley Perlman*

Department of Microbiology, University of Iowa, Iowa City, Iowa 52242

Received 14 July 2006/ Accepted 25 October 2006

Mouse hepatitis virus (MHV) does not induce interferon (IFN) production in fibroblasts or bone marrow-derived dendritic cells. In this report, we show that the essential IFN-ß transcription factors NF-{kappa}B and IFN regulatory factor 3 are not activated for nuclear translocation and gene induction during infection. However, MHV was unable to inhibit the activation of these factors and subsequent IFN-ß production induced by poly(I:C). Further, MHV infection did not inhibit IFN-ß production mediated by known host pattern recognition receptors (PRRs) (RIG-I, Mda-5, and TLR3). These results are consistent with the notion that double-stranded RNA, produced during MHV infection, is not accessible to cellular PRRs.

* Corresponding author. Mailing address: Department of Microbiology, University of Iowa, Bowen Science Building 3-730, Iowa City, IA 52242. Phone: (319) 335-8549. Fax: (319) 335-9999. E-mail: Stanley-Perlman{at}uiowa.edu.

{triangledown} Published ahead of print on 1 November 2006.

Journal of Virology, January 2007, p. 568-574, Vol. 81, No. 2
0022-538X/07/$08.00+0     doi:10.1128/JVI.01512-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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