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Journal of Virology, January 2007, p. 1037-1042, Vol. 81, No. 2
0022-538X/07/$08.00+0     doi:10.1128/JVI.01416-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Epstein-Barr Virus BZLF1 Gene, a Switch from Latency to Lytic Infection, Is Expressed as an Immediate-Early Gene after Primary Infection of B Lymphocytes{triangledown}

Wangrong Wen, Dai Iwakiri, Koji Yamamoto, Seiji Maruo, Teru Kanda, and Kenzo Takada*

Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan

Received 6 July 2006/ Accepted 22 October 2006

We demonstrate here that the Epstein-Barr virus (EBV) BZLF1 gene, a switch from latent infection to lytic infection, is expressed as early as 1.5 h after EBV infection in Burkitt's lymphoma-derived, EBV-negative Akata and Daudi cells and primary B lymphocytes. Since BZLF1 mRNA is expressed even when the cells are infected with EBV in the presence of anisomycin, an inhibitor of protein synthesis, its expression does not require prerequisite protein synthesis, indicating that BZLF1 is expressed as an immediate-early gene following primary EBV infection of B lymphocytes.

* Corresponding author. Mailing address: Department of Tumor Virology, Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo 060-0815, Japan. Phone: 81-11-706-5071. Fax: 81-11-706-7540. E-mail: kentaka{at}igm.hokudai.ac.jp.

{triangledown} Published ahead of print on 1 November 2006.

Journal of Virology, January 2007, p. 1037-1042, Vol. 81, No. 2
0022-538X/07/$08.00+0     doi:10.1128/JVI.01416-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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