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Journal of Virology, October 2007, p. 10818-10821, Vol. 81, No. 19
0022-538X/07/$08.00+0 doi:10.1128/JVI.01116-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,1 Department of Virology, University of Freiburg, D-79104 Freiburg, Germany,2 Department of Microbiology,3 Department of Medicine, Division of Infectious Diseases,4 Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, New York 100295
Received 23 May 2007/ Accepted 13 July 2007
Mice carrying a wild-type Mx1 gene (Mx1+/+) differ from standard laboratory mice (Mx1–/–) in being highly resistant to infection with common laboratory strains of influenza A virus. We report that Mx1 also protects mice against the pandemic human 1918 influenza virus and a highly lethal human H5N1 strain from Vietnam. Resistance to H5N1 of Mx1+/+ but not Mx1–/– mice was enhanced if the animals were treated with a single dose of exogenous alpha interferon before infection. Thus, the interferon-induced resistance factor Mx1 represents a key component of the murine innate immune system that mediates protection against epidemic and pandemic influenza viruses.
Published ahead of print on 25 July 2007.
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