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Journal of Virology, October 2007, p. 10815-10817, Vol. 81, No. 19
0022-538X/07/$08.00+0     doi:10.1128/JVI.00143-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Induction of Autophagy Does Not Affect Human Rhinovirus Type 2 Production{triangledown}

Marianne Brabec-Zaruba,1 Ursula Berka,1 Dieter Blaas,2 and Renate Fuchs1*

Department of Pathophysiology,1 Max F. Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry, Medical University of Vienna, Vienna, Austria2

Received 22 January 2007/ Accepted 16 July 2007

Induction of autophagy has been shown to be beneficial for the replication of poliovirus, a phenomenon that might also apply for other picornaviruses. We demonstrate that de novo synthesis of human rhinovirus type 2 (HRV2), an HRV of the minor receptor group, is unaffected by tamoxifen, rapamycin, and 3-methyladenine (3-MA), drugs either stimulating (tamoxifen and rapamycin) or inhibiting (3-MA) autophagic processes. Furthermore, LC3-positive vesicles (i.e., autophagosomes) are not induced upon infection. Therefore, multiplication of this particular picornavirus is not dependent on autophagy.

* Corresponding author. Mailing address: Department of Pathophysiology, Medical University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria. Phone: (43) 1 40 400-5127. Fax: (43) 1 40 400-5130. E-mail: renate.fuchs{at}meduniwien.ac.at

{triangledown} Published ahead of print on 1 August 2007.

Journal of Virology, October 2007, p. 10815-10817, Vol. 81, No. 19
0022-538X/07/$08.00+0     doi:10.1128/JVI.00143-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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