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Journal of Virology, September 2007, p. 9591-9595, Vol. 81, No. 17
0022-538X/07/$08.00+0     doi:10.1128/JVI.02776-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Evolutionary Processes among Sylvatic Dengue Type 2 Viruses{triangledown}

Nikos Vasilakis,1 Edward C. Holmes,2,3 Eric B. Fokam,4 Ousmane Faye,5 Mawlouth Diallo,5 Amadou A. Sall,5 and Scott C. Weaver1*

Center for Biodefense and Emerging Infectious Diseases and Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555-0609,1 Center for Infectious Disease Dynamics and Department of Biology, The Pennsylvania State University, University Park, Pennsylvania 16802,2 Fogarty International Center, National Institutes of Health, Bethesda, Maryland 20892,3 Department of Zoology and Botany, University of Buea, Buea, Cameroon,4 Institut Pasteur de Dakar, Dakar, Senegal5

Received 15 December 2006/ Accepted 12 June 2007

Sylvatic dengue viruses (DENV) are transmitted in an enzootic cycle between nonhuman primates and arboreal Aedes mosquitoes in Southeast Asia and West Africa. Although previous analyses have revealed the evolutionary processes among endemic (human) DENV, little is known about viral evolution in the sylvatic cycle. Through an analysis of 14 complete coding regions of sylvatic Dengue type 2 virus sampled over a 33-year period, we show that both the rate of evolutionary change and the pattern of natural selection are similar among endemic and sylvatic DENV, although the latter have a uniquely high frequency of positive selection in the NS4B protein gene. Our findings support a recent cross-species transmission event and suggest the possibility of future DENV reemergence from the sylvatic cycle.

* Corresponding author. Mailing address: University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0609. Phone: (409) 747-0758. Fax: (409) 747-2655. E-mail: sweaver{at}utmb.edu

{triangledown} Published ahead of print on 6 June 2007.

Journal of Virology, September 2007, p. 9591-9595, Vol. 81, No. 17
0022-538X/07/$08.00+0     doi:10.1128/JVI.02776-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Vasilakis, N., Durbin, A. P., da Rosa, A. P. A. T., Munoz-Jordan, J. L., Tesh, R. B., Weaver, S. C. (2008). Antigenic Relationships between Sylvatic and Endemic Dengue Viruses. Am J Trop Med Hyg 79: 128-132 [Abstract] [Full Text]  


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