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Journal of Virology, August 2007, p. 8827-8832, Vol. 81, No. 16
0022-538X/07/$08.00+0     doi:10.1128/JVI.00895-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Mamu-B*08-Positive Macaques Control Simian Immunodeficiency Virus Replication

Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin 53715,¹ Laboratory of Genomic Diversity, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland 21702,² Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53715,³ AIDS Vaccine Program/Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland 02172⁴

Received 26 April 2007/ Accepted 20 May 2007

Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B*08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SIV_mac239-infected Indian rhesus macaques revealed that Mamu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3% of progressors (P = 0.00001). Mamu-B*08 was also associated with a 7.34-fold decrease in chronic phase viremia (P = 0.002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers.

Published ahead of print on 30 May 2007.

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