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Journal of Virology, August 2007, p. 8827-8832, Vol. 81, No. 16
0022-538X/07/$08.00+0     doi:10.1128/JVI.00895-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Mamu-B*08-Positive Macaques Control Simian Immunodeficiency Virus Replication{triangledown}

John T. Loffredo,1 Jess Maxwell,1 Ying Qi,2 Chrystal E. Glidden,1 Gretta J. Borchardt,1 Taeko Soma,1 Alex T. Bean,1 Dominic R. Beal,1 Nancy A. Wilson,1 William M. Rehrauer,3 Jeffrey D. Lifson,4 Mary Carrington,2 and David I. Watkins1,3*

Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin 53715,1 Laboratory of Genomic Diversity, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland 21702,2 Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin 53715,3 AIDS Vaccine Program/Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland 021724

Received 26 April 2007/ Accepted 20 May 2007

Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B*08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SIVmac239-infected Indian rhesus macaques revealed that Mamu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3% of progressors (P = 0.00001). Mamu-B*08 was also associated with a 7.34-fold decrease in chronic phase viremia (P = 0.002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers.

* Corresponding author. Mailing address: Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, 555 Science Dr., Madison, WI 53711. Phone: (608) 265-3380. Fax: (608) 265-8084. E-mail: watkins{at}primate.wisc.edu

{triangledown} Published ahead of print on 30 May 2007.

Journal of Virology, August 2007, p. 8827-8832, Vol. 81, No. 16
0022-538X/07/$08.00+0     doi:10.1128/JVI.00895-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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