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Journal of Virology, August 2007, p. 8361-8366, Vol. 81, No. 15
0022-538X/07/$08.00+0     doi:10.1128/JVI.02717-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Function of the Respiratory Syncytial Virus Small Hydrophobic Protein{triangledown}

Sandra Fuentes,1,2 Kim C. Tran,3 Priya Luthra,4 Michael N. Teng,2,3,5 and Biao He1,2,4,5*

Department of Veterinary and Biomedical Sciences,1 Graduate Program in Pathobiology,2 Department of Biochemistry and Molecular Biology,3 Cell and Developmental Biology Option, The Huck Institutes of Life Sciences,4 Center of Molecular Immunology and Infectious Disease, Pennsylvania State University, University Park, Pennsylvania 168025

Received 8 December 2006/ Accepted 2 May 2007

Respiratory syncytial virus (RSV), a member of the Paramyxoviridae family, encodes a small hydrophobic (SH) protein of unknown function. Parainfluenza virus 5 (PIV5), a prototypical paramyxovirus, also encodes an SH protein, which inhibits tumor necrosis factor alpha (TNF-{alpha}) signaling. In this study, recombinant PIV5 viruses without their own SH but containing RSV SH (from RSV strain A2 or B1) in its place (PIV5{Delta}SH-RSV SH) and RSV lacking its own SH (RSV{Delta}SH) were generated and analyzed. The results indicate that the SH protein of RSV has a function similar to that of PIV5 SH and that it can inhibit TNF-{alpha} signaling.

* Corresponding author. Mailing address: Center of Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, 115 Henning Bldg., University Park, PA 16802. Phone: (814) 863-8533. Fax: (814) 863-6140. E-mail: bxh40{at}psu.edu

{triangledown} Published ahead of print on 9 May 2007.

Journal of Virology, August 2007, p. 8361-8366, Vol. 81, No. 15
0022-538X/07/$08.00+0     doi:10.1128/JVI.02717-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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