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Journal of Virology, August 2007, p. 8025-8029, Vol. 81, No. 15
0022-538X/07/$08.00+0     doi:10.1128/JVI.01771-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Estimating the Infectivity of CCR5-Tropic Simian Immunodeficiency Virus SIVmac251 in the Gut{triangledown}

David P. Wilson,1,3 Joseph J. Mattapallil,2 Matthew D. H. Lay,1 Lei Zhang,1 Mario Roederer,2 and Miles P. Davenport1*

Department of Haematology, Prince of Wales Hospital, and Centre for Vascular Research, University of New South Wales, Kensington, New South Wales, Australia,1 ImmunoTechnology Section, NIAID, NIH, Bethesda, Maryland 20892,2 National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, New South Wales, Australia3

Received 15 August 2006/ Accepted 5 May 2007

CD4+ T-cell depletion during acute human immunodeficiency virus infection occurs predominantly in the gastrointestinal mucosa. Using experimental data on SIVmac251 viral load in blood and CD4+ T cells in the jejunum, we modeled the kinetics of CD4+ T-cell infection and death and estimated the viral infectivity. The infectivity of SIVmac251 is higher than previously estimated for SHIV89.6P infection, but this higher infectivity is offset by a lower average peak viral load in SIVmac251. Thus, the dynamics of target cell infection and death are remarkably similar between a CXCR4- and a CCR5-tropic infection in vivo.

* Corresponding author. Mailing address: Centre for Vascular Research, University of New South Wales, Kensington, Sydney 2021, Australia. Phone: 61-293852762. Fax: 61-293851389. E-mail: m.davenport{at}unsw.edu.au

{triangledown} Published ahead of print on 16 May 2007.

Journal of Virology, August 2007, p. 8025-8029, Vol. 81, No. 15
0022-538X/07/$08.00+0     doi:10.1128/JVI.01771-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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