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Journal of Virology, August 2007, p. 7894-7901, Vol. 81, No. 15
0022-538X/07/$08.00+0     doi:10.1128/JVI.00555-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Evidence for Cooperative Transforming Activity of the Human Pituitary Tumor Transforming Gene and Human T-Cell Leukemia Virus Type 1 Tax{triangledown}

Sergey V. Sheleg,1,{dagger} Jean-Marie Peloponese,1,{dagger} Ya-Hui Chi,1 Yan Li,1 Michael Eckhaus,2 and Kuan-Teh Jeang1*

Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases,1 Veterinary Resources Program, Office of Research Services, National Institutes of Health, Bethesda, Maryland 208922

Received 15 March 2007/ Accepted 9 May 2007

Aneuploidy is frequent in cancers. Recently it was found that pituitary tumor transforming gene (PTTG; also called Pds1p or securin) is overexpressed in many different tumors. Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that primarily infects CD4+ T lymphocytes and causes adult T-cell leukemia. Here, we report that overexpression of human PTTG cooperated with the HTLV-I Tax oncoprotein in cellular transformation. Coexpression of Tax and PTTG enhanced chromosomal instability and neoplastic changes to levels greater than overexpression of either factor singularly. Cells that overexpressed both PTTG and Tax induced tumors more robustly in nude mice than cells that expressed either PTTG alone or Tax alone.

* Corresponding author. Mailing address: Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892. Phone: (301) 496-6680. Fax: (301) 480-3686. E-mail: kj7e{at}nih.gov

{triangledown} Published ahead of print on 16 May 2007.

{dagger} S.V.S. and J.-M.P. made equal contributions.

Journal of Virology, August 2007, p. 7894-7901, Vol. 81, No. 15
0022-538X/07/$08.00+0     doi:10.1128/JVI.00555-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Peloponese, J.-M. Jr., Yasunaga, J., Kinjo, T., Watashi, K., Jeang, K.-T. (2009). Peptidylproline cis-trans-Isomerase Pin1 Interacts with Human T-Cell Leukemia Virus Type 1 Tax and Modulates Its Activation of NF-{kappa}B. J. Virol. 83: 3238-3248 [Abstract] [Full Text]  


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