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Journal of Virology, July 2007, p. 7338-7350, Vol. 81, No. 14
0022-538X/07/$08.00+0     doi:10.1128/JVI.00062-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Protracted Course of Lymphocytic Choriomeningitis Virus WE Infection in Early Life: Induction but Limited Expansion of CD8+ Effector T Cells and Absence of Memory CD8+ T Cells{triangledown}

Elodie Belnoue, Paola Fontannaz-Bozzotti, Stéphane Grillet, Paul-Henri Lambert, and Claire-Anne Siegrist*

World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Departments of Pathology-Immunology and Pediatrics, University of Geneva, Geneva, Switzerland

Received 10 January 2007/ Accepted 30 April 2007

Viral infections in human infants frequently follow a protracted course, with higher viral loads and delayed viral clearance compared to viral infections in older children. To identify the mechanisms responsible for this protracted pattern of infection, we developed an infant infection murine model using the well-characterized lymphocytic choriomeningitis virus (LCMV) WE strain in 2-week-old BALB/c mice. In contrast to adult mice, in which viral clearance occurred as expected 8 days after infection, LCMV titers persisted for several weeks after infection of infant mice. LCMV-specific effector CD8+ T cells were elicited in infant mice and fully functional on day 7 but rapidly waned and could not be recovered from day 12 onwards. We show here that this results from the failure of LCMV-specific CD8+ T cells to expand and the absence of protective LCMV-specific memory CD8+ T cells. Under these early life conditions, viral control and clearance are eventually achieved only through LCMV-specific B cells that contribute to protect infant mice from early death or chronic infection.

* Corresponding author. Mailing address: World Health Organization Collaborating Center for Vaccinology and Neonatal Immunology, Departments of Pathology-Immunology and Pediatrics, University of Geneva, Centre Médical Universitaire, Rue Michel Servet 1, 1211 Geneva 4, Switzerland. Phone: 41 22 379 57 78. Fax: 41 22 379 58 01. E-mail: claire-anne.siegrist{at}medecine.unige.ch

{triangledown} Published ahead of print on 9 May 2007.

Journal of Virology, July 2007, p. 7338-7350, Vol. 81, No. 14
0022-538X/07/$08.00+0     doi:10.1128/JVI.00062-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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