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Journal of Virology, July 2007, p. 7306-7309, Vol. 81, No. 13
0022-538X/07/$08.00+0     doi:10.1128/JVI.02880-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Prion Protein Alleles Showing a Protective Effect on the Susceptibility of Sheep to Scrapie and Bovine Spongiform Encephalopathy{triangledown}

Gabriele Vaccari,1* Claudia D'Agostino,1 Romolo Nonno,1 Francesca Rosone,2 Michela Conte,1 Michele Angelo Di Bari,1 Barbara Chiappini,1 Elena Esposito,1 Luigi De Grossi,2 Francesco Giordani,2 Stefano Marcon,1 Luisella Morelli,1 Renata Borroni,1 and Umberto Agrimi1

Department of Food Safety and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy,1 Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana, Rome, Italy2

Received 29 December 2006/ Accepted 4 April 2007

The susceptibility of sheep to classical scrapie and bovine spongiform encephalopathy (BSE) is mainly influenced by prion protein (PrP) polymorphisms A136V, R154H, and Q171R, with the ARR allele associated with significantly decreased susceptibility. Here we report the protective effect of the amino acid substitution M137T, I142K, or N176K on the ARQ allele in sheep experimentally challenged with either scrapie or BSE. Such observations suggest the existence of additional PrP alleles that significantly decrease the susceptibility of sheep to transmissible spongiform encephalopathies, which may have important implications for disease eradication strategies.

* Corresponding author. Mailing address: Istituto Superiore di Sanità, Department of Food Safety and Veterinary Public Health, Viale Regina Elena 299, 00161 Rome, Italy. Phone: 39 06 4990 2139. Fax: 39 06 4938 7077. E-mail: gabriele.vaccari{at}iss.it

{triangledown} Published ahead of print on 18 April 2007.

Journal of Virology, July 2007, p. 7306-7309, Vol. 81, No. 13
0022-538X/07/$08.00+0     doi:10.1128/JVI.02880-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Laegreid, W. W., Clawson, M. L., Heaton, M. P., Green, B. T., O'Rourke, K. I., Knowles, D. P. (2008). Scrapie Resistance in ARQ Sheep. J. Virol. 82: 10318-10320 [Abstract] [Full Text]  


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