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Journal of Virology, July 2007, p. 7293-7296, Vol. 81, No. 13
0022-538X/07/$08.00+0     doi:10.1128/JVI.02467-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

A Borna Disease Virus Vector for Expression of Foreign Genes in Neurons of Rodents{triangledown}

Urs Schneider,* Andreas Ackermann, and Peter Staeheli*

Department of Virology, University of Freiburg, 79104 Freiburg, Germany

Received 9 November 2006/ Accepted 3 April 2007

An expression cassette for green fluorescent protein was successfully inserted at a site near the 5' end of the genome of Borna disease virus (BDV). When introduced into a mutant virus with highly active polymerase, the foreign gene was strongly expressed in neurons of infected rats. Since BDV can establish long-term persistence in the central nervous system of rodents, it may be used to engineer efficient vectors for specific delivery of foreign genes into highly differentiated neurons.

* Corresponding author. Mailing address: Department of Virology, University of Freiburg, Hermann-Herder-Strasse 11, D-79104 Freiburg, Germany. Phone: 49-761-203-6579. Fax: 49-761-203-5350. E-mail for Urs Schneider: urs.schneider{at}uniklinik-freiburg.de. E-mail for Peter Staeheli: peter.staeheli{at}uniklinik-freiburg.de

{triangledown} Published ahead of print on 11 April 2007.

Journal of Virology, July 2007, p. 7293-7296, Vol. 81, No. 13
0022-538X/07/$08.00+0     doi:10.1128/JVI.02467-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Poenisch, M., Wille, S., Schneider, U., Staeheli, P. (2009). Second-site mutations in Borna disease virus overexpressing viral accessory protein X. J. Gen. Virol. 90: 1932-1936 [Abstract] [Full Text]  
  • Poenisch, M., Wille, S., Ackermann, A., Staeheli, P., Schneider, U. (2007). The X Protein of Borna Disease Virus Serves Essential Functions in the Viral Multiplication Cycle. J. Virol. 81: 7297-7299 [Abstract] [Full Text]  


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