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Journal of Virology, July 2007, p. 7293-7296, Vol. 81, No. 13
0022-538X/07/$08.00+0     doi:10.1128/JVI.02467-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

A Borna Disease Virus Vector for Expression of Foreign Genes in Neurons of Rodents

Department of Virology, University of Freiburg, 79104 Freiburg, Germany

Received 9 November 2006/ Accepted 3 April 2007

An expression cassette for green fluorescent protein was successfully inserted at a site near the 5' end of the genome of Borna disease virus (BDV). When introduced into a mutant virus with highly active polymerase, the foreign gene was strongly expressed in neurons of infected rats. Since BDV can establish long-term persistence in the central nervous system of rodents, it may be used to engineer efficient vectors for specific delivery of foreign genes into highly differentiated neurons.

Published ahead of print on 11 April 2007.

This article has been cited by other articles:

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