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Journal of Virology, June 2007, p. 6761-6764, Vol. 81, No. 12
0022-538X/07/$08.00+0 doi:10.1128/JVI.02726-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Department of Molecular and Medical Pharmacology,1 Dental Research Institute, University of California, Los Angeles, California 90095,2 Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People's Republic of China3
Received 11 December 2006/ Accepted 19 March 2007
Open reading frame 24 (ORF24) of murine gammaherpesvirus 68 (MHV-68) is conserved among beta- and gammaherpesviruses; however, its function in viral replication has not been defined. Using MHV-68 as a model, we have identified ORF24 as being essential for viral replication. An ORF24-null virus was generated and shown to be defective in late gene expression. Expression of early genes, as well as viral genome replication, was not affected. Furthermore, the defect in late gene expression was likely due to a deficiency in transcription. Thus, we have identified an MHV-68 protein, ORF24, that is essential for the expression of viral late proteins yet dispensable for viral DNA replication.
Published ahead of print on 28 March 2007.
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