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Journal of Virology, June 2007, p. 6128-6133, Vol. 81, No. 11
0022-538X/07/$08.00+0     doi:10.1128/JVI.02627-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Human Serum Amyloid A Protein Inhibits Hepatitis C Virus Entry into Cells{triangledown}

Zhaohui Cai,1 Lei Cai,2 Jieyun Jiang,1 Kyung-Soo Chang,1 Deneys R. van der Westhuyzen,2 and Guangxiang Luo1*

Department of Microbiology, Immunology, and Molecular Genetics,1 Departments of Internal Medicine and Molecular and Cellular Biochemistry and Graduate Center for Nutritional Sciences, University of Kentucky College of Medicine, Lexington, Kentucky 405362

Received 28 November 2006/ Accepted 21 February 2007

Serum amyloid A (SAA) is an acute-phase protein induced by a variety of inflammatory stimuli, including bacterial and viral infections. SAA was recently found to function as an opsonin for gram-negative bacteria. We report here that SAA inhibited hepatitis C virus (HCV) infection in cultured cells. SAA reduced HCV infectivity in a dose-dependent manner when added during HCV infection but not after virus entry. SAA bound HCV virions and specifically blocked HCV entry but did not affect virus attachment. These findings suggest that SAA functions as part of the host innate immune defense mechanisms against HCV infection in humans.

* Corresponding author. Mailing address: Departments of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536. Phone: (859) 257-5577. Fax: (859) 257-8994. E-mail: gluo0{at}uky.edu

{triangledown} Published ahead of print on 28 February 2007.

Journal of Virology, June 2007, p. 6128-6133, Vol. 81, No. 11
0022-538X/07/$08.00+0     doi:10.1128/JVI.02627-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Burlone, M. E., Budkowska, A. (2009). Hepatitis C virus cell entry: role of lipoproteins and cellular receptors. J. Gen. Virol. 90: 1055-1070 [Abstract] [Full Text]  
  • Zhang, L., Du, J., Hu, Z., Han, G., Delafontaine, P., Garcia, G., Mitch, W. E. (2009). IL-6 and Serum Amyloid A Synergy Mediates Angiotensin II-Induced Muscle Wasting. J. Am. Soc. Nephrol. 20: 604-612 [Abstract] [Full Text]  
  • Timpe, J M, McKeating, J A (2008). Hepatitis C virus entry: possible targets for therapy. Gut 57: 1728-1737 [Full Text]  
  • von Hahn, T., Rice, C. M. (2008). Hepatitis C Virus Entry. J. Biol. Chem. 283: 3689-3693 [Full Text]  


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