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Journal of Virology, June 2007, p. 5978-5984, Vol. 81, No. 11
0022-538X/07/$08.00+0     doi:10.1128/JVI.02650-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

New Adenovirus Species Found in a Patient Presenting with Gastroenteritis{triangledown}

Morris Saffold Jones II,1* Balázs Harrach,5 Robert D. Ganac,1 Mary M. A. Gozum,1 Wilfred P. dela Cruz,1 Brian Riedel,2 Chao Pan,2 Eric L. Delwart,3,4 and David P. Schnurr2

Clinical Investigation Facility, David Grant USAF Medical Center, 101 Bodin Circle, Travis Air Force Base, California 94535,1 Viral and Rickettsial Disease Laboratory, California Department of Health Services, 850 Marina Bay Parkway, Richmond, California 94804,2 Blood Systems Research Institute, 270 Masonic Ave., San Francisco, California 94118,3 University of California, San Francisco, Department of Medicine, San Francisco, California 94118,4 Veterinary Medical Research Institute, Hungarian Academy of Sciences, H-1581 Budapest, Hungary5

Received 30 November 2006/ Accepted 6 March 2007

An unidentified agent was cultured in primary monkey cells at the Los Angeles County Public Health Department from each of five stool specimens submitted from an outbreak of gastroenteritis. Electron microscopy and an adenovirus-specific monoclonal antibody confirmed this agent to be an adenovirus. Since viral titers were too low, complete serotyping was not possible. Using the DNase-sequence-independent viral nucleic acid amplification method, we identified several nucleotide sequences with a high homology to human adenovirus 41 (HAdV-41) and simian adenovirus 1 (SAdV-1). However, using anti-SAdV-1 sera, it was determined that this virus was serologically different than SAdV-1. Genomic sequencing and phylogenetic analysis confirmed that this new adenovirus was so divergent from the known human adenoviruses that it was not only a new type but also represented a new species (human adenovirus G). In a retrospective clinical study, this new virus was detected by PCR in one additional patient from a separate gastroenteritis outbreak. This study suggests that HAdV-52 may be one of many agents causing gastroenteritis of unknown etiology.

* Corresponding author. Mailing address: Clinical Investigation Facility, David Grant USAF Medical Center, 101 Bodin Circle, Travis AFB, CA 94535. Phone: (415) 279-1869. Fax: (707) 423-7267. E-mail: drmorrisj{at}yahoo.com

{triangledown} Published ahead of print on 14 March 2007.

Journal of Virology, June 2007, p. 5978-5984, Vol. 81, No. 11
0022-538X/07/$08.00+0     doi:10.1128/JVI.02650-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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