This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Goodier, M. R.
Right arrow Articles by Gotch, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Goodier, M. R.
Right arrow Articles by Gotch, F.

 Previous Article  |  Next Article 

Journal of Virology, January 2007, p. 430-433, Vol. 81, No. 1
0022-538X/07/$08.00+0     doi:10.1128/JVI.01567-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

NKG2C+ NK Cells Are Enriched in AIDS Patients with Advanced-Stage Kaposi's Sarcoma{triangledown}

Martin R. Goodier,1* C. M. Mela,1 A. Steel,2 B. Gazzard,2 M. Bower,3 and F. Gotch1

Department of Immunology, Imperial College London,1 Directorate of HIV-GUM,2 Clinical Oncology Unit, Chelsea and Westminster Hospital, London, United Kingdom3

Received 19 September 2006/ Accepted 4 October 2006

Kaposi's sarcoma (KS) is an AIDS-defining condition in individuals with human immunodeficiency virus type 1 infection. We investigated the phenotype and function of the NKG2C+ NK cell population in individuals with AIDS and Kaposi's sarcoma. The staging of AIDS KS patients according to the AIDS Clinical Trial Group criteria revealed that patients with the S1 disease stage have a significantly higher proportion of NKG2C+ cells than those with the S0 disease stage. NKG2C+ cells from S1-stage patients are highly enriched for the expression of KIR3DL1, are depleted of NKp46, and respond poorly to major histocompatibility complex class I-positive target cells. These data demonstrate a link between NK cell phenotype and function and disease prognosis in AIDS.

* Corresponding author. Mailing address: Department of Immunology, Imperial College London, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom. Phone: (44) 208 746 5987. Fax: (44) 208 746 5997. E-mail: m.goodier{at}imperial.ac.uk.

{triangledown} Published ahead of print on 11 October 2006.

Journal of Virology, January 2007, p. 430-433, Vol. 81, No. 1
0022-538X/07/$08.00+0     doi:10.1128/JVI.01567-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»