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Journal of Virology, January 2007, p. 423-426, Vol. 81, No. 1
0022-538X/07/$08.00+0     doi:10.1128/JVI.01455-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Early Resolution of Herpes Simplex Virus Type 2 Infection of the Murine Genital Tract Involves Stimulation of Genital Parenchymal Cells by Gamma Interferon{triangledown}

Melanie D. Bird,1,{dagger} Chin-Fun Chu,2 Alison J. Johnson,3 and Gregg N. Milligan2,3,4*

Department of Pathology,1 Department of Pediatrics,2 Department of Microbiology and Immunology,3 Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, Texas 775554

Received 10 July 2006/ Accepted 13 October 2006

Early clearance of a thymidine kinase-deficient strain of herpes simplex virus type 2 from the female genital tract required T-cell-produced gamma interferon (IFN-{gamma}). Transfer of activated CD8+ T cells to irradiated C57BL/6 mice resulted in rapid virus clearance, but clearance was greatly delayed in recipients deficient in the IFN-{gamma} receptor (IFN-{gamma}R). Early virus clearance was demonstrated in radiation chimeras in which IFN-{gamma}R expression was limited to parenchymal cells, but resolution was significantly delayed in chimeras deficient in IFN-{gamma}R expression and chimeras expressing IFN-{gamma}R only on hematopoietic cells. Together, these results suggest that early IFN-{gamma}-mediated protection was manifested mainly by stimulation of genital parenchymal cells.

* Corresponding author. Mailing address: University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-0436. Phone: (409) 747-8145. Fax: (409) 747-8150. E-mail: gnmillig{at}utmb.edu.

{triangledown} Published ahead of print on 25 October 2006.

{dagger} Present address: Dept. of Microbiology and Immunology, Northwestern University, Chicago, IL 60611.

Journal of Virology, January 2007, p. 423-426, Vol. 81, No. 1
0022-538X/07/$08.00+0     doi:10.1128/JVI.01455-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.



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