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Journal of Virology, January 2007, p. 416-422, Vol. 81, No. 1
0022-538X/07/$08.00+0     doi:10.1128/JVI.02336-05
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Role for Nonstructural Protein 1 of Severe Acute Respiratory Syndrome Coronavirus in Chemokine Dysregulation

Anna H. Y. Law, Davy C. W. Lee, Benny K. W. Cheung, Howard C. H. Yim, and Allan S. Y. Lau^*

Immunology Research Laboratory, Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, China

Received 7 November 2005/ Accepted 5 October 2006

Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus. Since its associated morbidity and mortality have been postulated to be due to immune dysregulation, we investigated which of the viral proteins is responsible for chemokine overexpression. To delineate the viral and cellular factor interactions, the role of four SARS coronavirus proteins, including nonstructural protein 1 (nsp-1), nsp-5, envelope, and membrane, were examined in terms of cytokine induction. Our results showed that the SARS coronavirus nsp-1 plays an important role in CCL5, CXCL10, and CCL3 expression in human lung epithelial cells via the activation of NF-B.

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* Corresponding author. Mailing address: Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, China. Phone: 852-2855-4269. Fax: 852-2855-1523. E-mail: asylau{at}hku.hk.

Published ahead of print on 11 October 2006.

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Journal of Virology, January 2007, p. 416-422, Vol. 81, No. 1
0022-538X/07/$08.00+0     doi:10.1128/JVI.02336-05
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

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